Vitamin d3 levels in patients of left ventricular hypertrophy in essential hypertension; a case control study

Abstract

Objective: Analysis of serum cholecalciferol in essential hypertension and its correlation with left ventricular hypertrophy (LVH).
Methodology: This cross sectional study was conducted at Department of Medicine, Isra University, Hyderabad from September 2017 to March 2018. Hundred controls and Hundred diagnosed cases of essential hypertension with left ventricular hypertrophy were selected. LVH was estimated by echocardiography. Blood samples were centrifuged at 4000 rpm (10 minutes) to separate sera for biochemical estimation of serum cholecalciferol, serum calcium, serum phosphate and alkaline phosphatase. Statistical analysis was performed on statistical software (SPSS 22.0) and Microsoft excel. Continuous variables were presented as mean ± S.D as analysed by Student`s t-test. Statistical significance was taken at 95% confidence interval (P-value ≤0.05).
Results: Serum cholecalciferol was low in cases 22.84±5.10 ng/dl compared to controls 47.09±7.65 ng/dl (p=0.0001). Mean ± SD interventricular septum and posterior wall thickness was noted as 12.39±1.82 mm in cases. Serum cholecalciferol revealed negative correlation with LVH (r= - 0.774, p=0.0001).
Conclusion: Low serum cholecalciferol was found in the essential hypertension with left ventricular hypertrophy.