impact of thyroid hormones on brain development
DOI:
https://doi.org/10.48036/apims.v15i4.251Keywords:
Thyroid hormones (THs), Deiodenases, Thyroid receptors, Glial cells, Brain developmental processeAbstract
Thyroid hormones (THs) including triiodothyronine (T3) and tetraiodothyronine (T4) perform an essential role in brain development. The active form (T3) of THs is produced after metabolism and transported in different areas of brain. This actve form acts either by interacting with different types of glial cells or by mediating the expression of various genes for producing typical growth proteins. These protiens control many brain developmental processes such as synaptogenesis, neurogenesis, cell proliferation, differentiation, migration and maturation. During pregnancy the inadequate intake of iodine (I2) by pregnant mothers is associated with clinical manifestations because early brain development is totally dependent upon THs coming from maternal origin. A reduction in THs can alter these specific brain developmental processes, thereby changing the cognitive performance. On other hand THs supplementation can recover the normal circumstances.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.