Noninvasive Ventilation plus Standard Medical Therapy versus Medical Therapy Alone in Acute Hypercapnic Respiratory Failure due to Post-tuberculous COPD

Authors

  • Rizwan Athar Athar Islamabad Medical Complex Hospital, Islamabad
  • Rizwan Ahmad Federal Government Polyclinic Hospital, Islamabad
  • Tariq Hussain PAEC General Hospital, Islamabad
  • Muaz Mubashir Federal Government Polyclinic Hospital, Islamabad
  • Mehdi Hassan Naqvi Federal Government Polyclinic Hospital, Islamabad
  • Hassan Atique Federal Government Polyclinic Hospital

Keywords:

Chrоnic Obstructive Airway Disease, COPD, Non-invasive Ventilation, Acute Hypercapnic Respiratory Failure

Abstract

Objective: To compare the efficacy of noninvasive ventilation (NIV) plus standard medical therapy versus standard medical therapy alone in acute hypercapnic respiratory failure due to post-tuberculous chronic obstructive lung disease (COPD).

Material & Methods: This quasi-experimental study was done at the Department of Pulmonology, Fauji Foundation Hospital, Rawalpindi between 1st August 2019 to 1st January 2020 after ethical approval. After informed consent, 80 post-tuberculous COPD patients were enrolled by non-probability sampling. Patients were allocated into two groups with 40 participants in each group; Group A (intervention group) received NIV in addition to standard medical therapy, whereas patients in Group B were given standard medical therapy alone. Following history and examination, baseline arterial blood gases (ABGs) were done.

Results: Mean change in pH, paCO2, paO2 and respiratory rate in group A and group B at 6 hours were 7.38+0.06 vs 7.30+0.03, 44.63+8.24 vs 64.26+5.71, 73.55+14.94 vs 72.67+9.49 and 20.20+2.40 vs 25.32+3.18, respectively. Noninvasive ventilation plus standard medical therapy was more effective than medical therapy alone, with statistically significant results for pH, paCO2, and respiratory rate (p-value=0.001). The patient outcomes had no significant relation with age, gender and duration of post-tuberculous COPD (p-value ?0.10).

C?nclusi?n: Noninvasive ventilation plus standard treatment yields superior results to standard treatment alone in acute hypercapnic respiratory failure due to post-TB COPD. We recommend combination therapy in such patients.

Author Biographies

Rizwan Athar Athar, Islamabad Medical Complex Hospital, Islamabad

Consultant Pulmonologist

 

Rizwan Ahmad, Federal Government Polyclinic Hospital, Islamabad

Consultant Medical Specialist

Associate Professor, Department of Medicine

Tariq Hussain, PAEC General Hospital, Islamabad

Consultant Medical Specialist

Muaz Mubashir, Federal Government Polyclinic Hospital, Islamabad

Consultant Medical Specialist

Mehdi Hassan Naqvi, Federal Government Polyclinic Hospital, Islamabad

Consultant Medical Specialist

Hassan Atique, Federal Government Polyclinic Hospital

Assistant Professor, Department of Medicine

Published

2024-07-19

Issue

Section

Original Articles