ROLE OF INTRACAMERAL ANTIBIOTICS AS PROPHYLAXIS AGAINST INFECTION IN CATARACT SURGERY

Abstract

ABSTRACT

OBJECTIVE:

This study was conducted to understand the effects of intracameral moxifloxacin in decreasing the incidence of postoperative endophthalmitis after cataract surgery.

MATERIAL AND METHOD:

This was a prospective interventional randomized study conducted in Ophthalmology department, Fauji Foundation Hospital, Rawalpindi, from June 2022 to November 2022.  A total of 90 eyes of 90 patients were selected after approval from ethics committee from the Institutional Review Board. Patients were divided into two groups – Group A, received one drop of 5% povidone-iodine 15 minutes before surgery and postoperative antibiotics eye drops 4 times per day for 10 days; group B received the same prophylaxis for endophthalmitis as group A, plus an IC injection of 0.05 mL of commercially available moxifloxacin hydrochloride at 5.45 mg/mL immediately after IOL implant. After intervention, both groups were followed up at one, seven, and thirty days post surgery. Patients were also observed for endophthalmitis. SPSS-26 was used for data analysis.

RESULTS:

The overall mean age in this study was 60.4 + 8.6. Most of the patients were female in both groups i.e. around 87%. None of the case of endophthalmitis found in either group.

CONCLUSION:

On the basis of our study findings, we conclude that the use of intracameral antibiotics should not be considered as “standard of care†in order to prevent the occurrence of endophthalmitis in cataract surgeries.

KEY WORDS:

Cataract surgery, endophthalmitis, intracameral antibiotic, moxifloxacin