Diagnostic accuracy of endoscopic findings in patients with celiac disease

Abstract

Objective: To determine the diagnostic accuracy of endoscopic findings in patients with celiac disease, keeping histopathology as gold standard at Isra University Hospital Hyderabad.

Methodology: This descriptive study was conducted at Gastroenterology department of Isra University Hospital, from June 2017 to December 2017. All the patients with age between 20-50 years as suspected cases of celiac disease and either of gender were included. Patients underwent upper gastrointestinal endoscopy and if their duodenal folds showed any finding related to celiac disease, and then specimens for biopsies were taken. The entire specimens immediately were sent to the diagnostic laboratory for the histopathology. All the data was recorded in the predesigned Proforma and analyzed by SPSS version 20.

Results: Total 112 patients of celiac disease were studied, most of the patients 73.2% were found with age group of 20-30 years. Abdominal distension was most common among 80.4%. Out of all 49.1% patients had disease duration 11-15 weeks. All patients had endoscopic findings suggestive of celiac disease. According to the histological findings regarding celiac disease, 78.6% had positive histological findings and 21.4% had negative histological findings. Diagnostic accuracy endoscopic sensitivity was 100% and specificity was 24%. Negative predictive value was 0% and positive predictive value was 78%.

Conclusion: It was concluded that endoscopy showed 100% sensitivity in the diagnosis of celiac disease by taking histopathology as gold standard. It is a reliable safe and less complicated diagnostic tool for celiac disease