Association between Hyperuricemia and Ischemic Stroke in patients admitted in Medical ward in a tertiary care hospital Multan

Abstract

Objective: To assess the association of Hyperuricemia with Ischemic Stroke

Methodology: This case-control study was carried out at the department of Medicine Nishtar 2 Tertiary Care Hospital in Multan from June 2023 to Dec 2023.  
At the time of admission, the serum uric acid level was tested in addition to other standard laboratory tests. Patients' information was gathered using a pre-made proforma only after written informed permission was obtained from the individuals, their spouses, or relatives in the case of patients with aphasia or decreased awareness. Version 24 of the statistical program for the social sciences (SPSS) was used to analyze the data. A p-value of less than 0.05 and an OR greater than one were deemed statistically significant.

Results: In the current study, 60 patients were cases and 60 were healthy control. In cases there were 33 (55%) males and 27 (45%) females while in healthy control, the males were 30 (50%) while females were also 30 (50%). In patients with ischemic stroke, the frequency of hyperuricemia was 26 (43.33%), while in controls, it was 15 (25%). Compared to controls, ischemic stroke patients had a 3.11-fold increased incidence of hyperuricemia. Accordingly, hyperuricemia (p=0.002) is a substantial risk factor for ischemic stroke. In individuals aged 30 to 50, ischaemic stroke and hyperuricemia were significantly associated (p = 0.001). Additionally, ischaemic stroke patients had a 4.15-fold increased incidence of hyperuricemia compared to control subjects. On the other hand, there was no significant correlation (p = 0.29) between hyperuricemia and ischaemic stroke in the 51–70 age range. Additionally, there was a 2.1-fold increased incidence of hyperuricemia in ischaemic stroke patients.

Conclusion: Patients with ischemic stroke had a considerably greater prevalence of hyperuricemia (43.33%). Furthermore, those who have had an ischemic stroke are 3.11 times more likely to get hyperuricemia. Hyperuricemia may thus be looked at as an additional ischemic stroke risk factor. However, further study is required before regular uric acid levels may be advised.