Correlation of Left Atrial Volume Index with Pro-BNP in Heart Failure with Preserved Ejection Fraction

Abstract

Objective: To determine the correlation between left atrial (LA) volume index and Pro- BNP in heart failure patients with preserved ejection fraction.

Methodology: This descriptive Cross-Sectional Study was conducted at Department of Cardiology, Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro, Pakistan, during Six months after the approval of synopsis from March 26, 2021 to September 25, 2021. All patients who fulfilled the inclusion criteria and visited to LUMHS, Jamshoro were included in the study. Informed consent was taken after explaining the procedure, risks and benefits of the study. Peripheral venous blood samples were obtained for assessment of pro- BNP level. A detailed comprehensive echocardiography was performed in all patients. All the collected data were entered into the proforma attached at the end and used electronically for research purpose.

Results: The age of the patients ranged from 19 to 59 years with a median of 58 with interquartile range 12. In distribution of gender, 20 (60.5%) patients were male while 13 (39.4%) were female. Pearson’s correlation coefficient showed weak and non-significantly linear correlation between left atrial volume index and Pro-BNP levels i.e. (r= 0.134) in the region P < 0.05.

Conclusion: It is to be concluded that there was a weak correlation between left atrial volume index and Pro-BNP levels. More studies are necessary to evaluate the statistical association with a larger sample size and with more parameters in multiple study centers in Pakistan are needed to validate the findings of the present study.