Assessment of Psoriasis Severity Using Psoriasis Area and Severity Index (PASI) and its Association with Lipid Profile Parameters

Authors

  • Javed Iqbal lecturer Physiology Bilawal Medical College LUMHS Jamshoro
  • Aamir Hussain Associate Professor Physiology Department Bilawal Medica College LUMHS Jamshoro
  • Rizwan Ali Talpur Assistant Professor Physiology Department Bilawal Medical LUMHS Jamshoro
  • Hafiz Bashir Ahmed Kalhoro Assistant Professor Dermatology Department LUMHS Jamshoro
  • Hanozia Shah Assistant Professor Physiology Department Bilawal Medical LUMHS Jamshoro
  • Andleeb lecturer Biochemistry Bilawal Medical College LUMHS Jamshoro

Keywords:

soriasis Area Severity Index, Total cholesterol

Abstract

Objective: To explore potential association between specific lipid profile parameters and PASI scores in psoriatic patients at a tertiary care Hospital.
Methods: A descriptive cross-sectional study was carried out on patients attending the skin outpatient department and the Diagnostic Research Laboratory of the Department of Physiology at Liaquat University of Medical & Health Sciences Jamshoro/Hyderabad, from February to August 2022. Diagnosed patients of Psoriasis between 18 and 50 years, male and female were included. A 5ml blood sample was taken from each participant in fasting and the samples were used to perform a lipid profile analysis. All financial costs related to the investigations were covered by the researchers. A self-made detailed questionnaire was employed to collect demographic information and various study-related variables.
Results: The average age of patients with psoriasis was 45.99±10.33 (range 18-60 years). Out of the total 102 patients, 76 (74.5%) were male patients and 26 (25.5%) were female. The mean duration of psoriasis was 6.46 ± 4.49 years. For total cholesterol, 60 patients (58.8%) had increased levels > 200 mg/dL, in 68 patients (66.7%) low-density lipoprotein (LDL), increased levels > 130 mg/dL, in terms of high-density lipoprotein (HDL), in (57.8%) patients it was <40 mg/dL, while for triglycerides, in (87.3%) patients had increased levels > 150 mg/dL. Patients with moderate and severe psoriasis exhibited higher rates of abnormal lipid profiles compared to those with mild psoriasis. Significant p-values were found for total cholesterol, LDL, and HDL levels, indicating associations with psoriasis severity. However, triglyceride levels showed no significant difference across the severity groups.
Conclusion: This study revealed elevated lipid profiles among psoriatic patients, potentially contributing to lipid profile abnormalities. The high frequency of dyslipidemia observed is closely linked to the severity of psoriasis.

Author Biography

Javed Iqbal, lecturer Physiology Bilawal Medical College LUMHS Jamshoro



Published

2024-06-11

Issue

Section

Original Articles