Comparison of Discharge Readiness Between Propofol Plus Dexmedetomidine Combination and Propofol Plus Ketorolac in Patients Undergoing Dilation and Curettage

Abstract

Objective:  to evaluate the effect of combination of drugs on discharge readiness of the patient after dilation and curettage (D&C).

Methodology: This is prospective randomized trial in which we compare two randomized groups of patients Group 1 received propofol and ketorolac while Group 2 received combination of propofol and dexmedetomidine. Female patients Undergoing D&C, having age 25-60 years and ASA I and II status were included. Patients with cognitive impairment, disabilities and ambulatory problems, drug allergy, diabetics, body weight more than 110 kg and patients with significant renal or hepatic impairment were excluded. Discharge readiness was measured as MPADSS score of ? 9 at 30 minutes from the last dose administered, MPADSS was measured by using scoring system as described in methodology.

Results: The study found a significant association between propofol and dexmedetomidine and discharge readiness, with a value of 0.01 for age and 0.02 for propofol consumption in mg. However, there was not a significant association between propofol and dexmedetomidine and discharge readiness, indicated by values of 0.252 for height, 0.465 for weight, and 0.08 for BMI. The value of >9 in 30 min of MPADSS scoring system in indicates that there was a significant association between the between the propofol and Dexmedetomidine and discharge readiness

Conclusion: Discharge readiness is higher in propofol plus dexmedetomidine group compared to propofol plus ketorolac group on MPADSS discharge scale.

Keywords: Discharge readiness, Dilation and curettage, Propofol Ketorolac, dexmedetomidine