Cassia angustifolia – a potential anti-inflammatory agent in allergic asthma in rats

Authors

  • Dr. Sehrish Ijaz Post Graduate Medical Institute, Lahore.
  • Dr. Amer Hassan Siddiqui Post Graduate Medical Institute, Lahore.
  • Dr. Sabeen Irshad Allama Iqbal Medical College, Lahore.
  • Dr. Asma Inam Azra Naheed Medical College, Lahore.
  • Dr. Sadia Ikram HBS Medical and Dental College
  • Dr. Naima Shakeel Post Graduate Medical Institute, Lahore.

Keywords:

Dexamethasone, Cassia angustifolia, emodin, allergic asthma

Abstract

Introduction

Asthma is a chronic inflammatory disease of airway passages. Bronchial hyper responsiveness (BHR) results in increased production of mucous, narrow airways, edema and remodeling of bronchial tissues. Adverse effects of standard drugs limit the usefulness of these drugs. Cassia angustifolia, possesses anti-inflammatory properties that may be of potential benefit in asthma treatment.

Aims & Objective

The aim of study was to identify anti-inflammatory effects of Cassia angustifolia in allergic airway disease in comparison to emodin and dexamethasone.

Material & Method

This experimental study was conducted at animal house of Postgraduate Medical Institute, Lahore, Pakistan from February 2022 to March 2022 in which 42 male Sprague dawley rats were divided into 7 groups having 6 rats in each group. Group I (Normal control group), Group II (Diseased control group), Group III (Dexamethasone Control group), Group IV (Emodin Control group), Group V, VI, and VII were low, medium and high dose of Cassia angustifolia leaf ethanolic extract treated groups. Asthma was induced in all rats except the rats of normal control group at the start of the study by sensitizing rats with intraperitoneal injection of Ovalbumin on day 0 and 14. They were challenged with nebulization of 1% w/v ovalbumin solution on days 22, 23 and 24. Respective drugs were given from day 15 to 24 as twice oral daily doses. Blood samples were taken at day 25 via cardiac puncture. TLC, eosinophil count, IgE antibodies and IL-13 were measured using commercially available kits.

Results & Conclusion

Cassia angustifolia in higher doses has comparable anti-inflammatory effect to emodin and dexamethasone. The effect of low and medium doses of Cassia angustifolia was not comparable and was weaker than emodin and dexamethasone.

Author Biographies

Dr. Amer Hassan Siddiqui, Post Graduate Medical Institute, Lahore.

Assistant Professor of Pharmacology

Dr. Sabeen Irshad, Allama Iqbal Medical College, Lahore.

Associate Professor of Pharmacology

Dr. Asma Inam, Azra Naheed Medical College, Lahore.

Associate Professor of Pharmacology

Dr. Sadia Ikram, HBS Medical and Dental College

Associate Professor of Pharmacology

Dr. Naima Shakeel, Post Graduate Medical Institute, Lahore.

Associate Professor of Physiology

Published

2024-06-11

Issue

Section

Original Articles